Supporting Information for Mutation bias favors protein folding stability in the evolution of small populations
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چکیده
• Fig. 1: Phase diagram • Fig. 2: Approach to the stationary distribution of fitness • Fig. 3: Large population limit of the optimal mutation bias • Fig. 4: Difference in selective coefficients versus population size • Fig. 5: Stability and reduction in sequence entropy versus S • Fig. 6: Mutation bias dependence of |∂σ/∂x|x=1 in the neutral limit. • Fig. 7: Scatter plot of the optimal codon usage (estimating the effective population size) versus GC content at third codon position for prokaryotic species • Fig. 8: Histogram of the GC content from the previous figure.
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Mutation Bias Favors Protein Folding Stability in the Evolution of Small Populations
Mutation bias in prokaryotes varies from extreme adenine and thymine (AT) in obligatory endosymbiotic or parasitic bacteria to extreme guanine and cytosine (GC), for instance in actinobacteria. GC mutation bias deeply influences the folding stability of proteins, making proteins on the average less hydrophobic and therefore less stable with respect to unfolding but also less susceptible to misf...
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